Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease
Parunyou Julayanont MD
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorMélanie Brousseau SWT
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Search for more papers by this authorHoward Chertkow MD
Bloomfield Center for Research in Aging, Lady Davis Institute, General Hospital, Montreal, Quebec, Canada
Department of Clinical Neurosciences and Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Research Center, University Institute of Geriatrics, University of Montreal, Montreal, Quebec, Canada
Search for more papers by this authorNatalie Phillips PhD
Bloomfield Center for Research in Aging, Lady Davis Institute, General Hospital, Montreal, Quebec, Canada
Center for Research in Human Development, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Search for more papers by this authorCorresponding Author
Ziad S. Nasreddine MD
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Department of Clinical Neurosciences and Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Address correspondence to Dr. Ziad S. Nasreddine, Center for Diagnosis and Research on Alzheimer's Disease CEDRA/Neuro Rive- Sud Memory Clinic, 4896 Taschereau Boulevard Suite 250, Greenfield Park, Québec, Canada J4V 2J2. E-mail: [email protected]Search for more papers by this authorParunyou Julayanont MD
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorMélanie Brousseau SWT
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Search for more papers by this authorHoward Chertkow MD
Bloomfield Center for Research in Aging, Lady Davis Institute, General Hospital, Montreal, Quebec, Canada
Department of Clinical Neurosciences and Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Research Center, University Institute of Geriatrics, University of Montreal, Montreal, Quebec, Canada
Search for more papers by this authorNatalie Phillips PhD
Bloomfield Center for Research in Aging, Lady Davis Institute, General Hospital, Montreal, Quebec, Canada
Center for Research in Human Development, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Search for more papers by this authorCorresponding Author
Ziad S. Nasreddine MD
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada
Department of Clinical Neurosciences and Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Address correspondence to Dr. Ziad S. Nasreddine, Center for Diagnosis and Research on Alzheimer's Disease CEDRA/Neuro Rive- Sud Memory Clinic, 4896 Taschereau Boulevard Suite 250, Greenfield Park, Québec, Canada J4V 2J2. E-mail: [email protected]Search for more papers by this authorAbstract
Objectives
To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
Design
Retrospective chart review.
Setting
Community-based memory clinic.
Participants
Individuals meeting Petersen's MCI criteria (N = 165).
Measurements
Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.
Results
One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%).
Conclusion
Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
Supporting Information
| Filename | Description |
|---|---|
| jgs12742-sup-0001-TabS1-S5_FigS1.docxapplication/docx, 44.3 KB | Figure S1. Receiver operating characteristic curves of the Memory Index Score and the education-corrected Montreal Cognitive Assessment (MoCA) total score in prediction of conversion to Alzheimer's disease in individuals with mild cognitive impairment. Table S1. Age- and education-adjusted cutoff scores for each cognitive domain. Table S2. Baseline and follow-up activity of daily living (ADL) scores according to mild cognitive impairment (MCI) Group. Table S3. Demographic features and Montreal Cognitive Assessment (MoCA) items and cognitive domain index scores according to mild cognitive impairment (MCI) Group (N = 165). Table S4. Mild cognitive impairment (MCI) subtypes and conversion rates. Table S5. Area under the receiver operating characteristic curve (AUC) for the cognitive domain index scores to predict conversion from mild cognitive impairment to Alzheimer's disease (N = 165). |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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