Volume 56, Issue 7 p. 1236-1243

Decisional Capacity for Research Participation in Individuals with Mild Cognitive Impairment

Angela L. Jefferson PhD

Angela L. Jefferson PhD

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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Susan Lambe EdM

Susan Lambe EdM

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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David J. Moser PhD

David J. Moser PhD

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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Laura K. Byerly BA

Laura K. Byerly BA

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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Al Ozonoff PhD

Al Ozonoff PhD

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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Jason H. Karlawish MD

Jason H. Karlawish MD

From the * Alzheimer's Disease Center and Department of Neurology, School of Medicine, and Department of Psychology, University of Massachusetts at Boston, Boston, Massachusetts § Department of Psychiatry, University of Iowa, Iowa City, Iowa; Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts # Department of Medicine, Division of Geriatric Medicine, Center for Bioethics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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First published: 07 August 2008
Citations: 72
Address correspondence to Angela L. Jefferson, PhD, Boston University School of Medicine, Alzheimer's Disease Center, Robinson Complex, Suite 7800, 715 Albany Street, Boston, MA 02118. E-mail: [email protected]

A portion of these data were presented at the 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 2006.

Abstract

OBJECTIVES: To assess decisional capacity performance and the neuropsychological correlates of such performance to better understand higher-level instrumental activities of daily living in individuals with mild cognitive impairment (MCI).

DESIGN: Cross-sectional.

SETTING: Research center, medical center, or patient's home.

PARTICIPANTS: Forty participants with MCI and 40 cognitively normal older controls (NCs) aged 60 to 90 (mean age±standard deviation 73.3±6.6; 54% female).

MEASUREMENTS: Capacity to provide informed consent for a hypothetical, but ecologically valid, clinical trial was assessed using the MacArthur Competence Assessment Tool for Clinical Research. Neuropsychological functioning was assessed using a comprehensive protocol.

RESULTS: Adjusted between-group comparisons yielded significant differences for most decisional capacity indices examined, including Understanding (P=.001; NC>MCI) and Reasoning (P=.002; NC>MCI). Post hoc analyses revealed that participants with MCI who were categorized as capable of providing informed consent according to expert raters had higher levels of education than those who were categorized as incapable.

CONCLUSION: The findings suggest that many individuals with MCI perform differently on a measure of decisional capacity than their NC peers and that participants with MCI who are incapable of providing informed consent on a hypothetical and complex clinical trial are less educated. These findings are consistent with prior studies documenting functional and financial skill difficulties in individuals with MCI.